| Description | CS-0777 is a potent, selective, and orally active S1P1 agonist (sphingosine 1-phosphate receptor modulator). |
| Synonyms | CS0777, CS 0777 |
| molecular weight | 422.45 |
| Molecular formula | C21H31N2O5P |
| CAS | 840523-39-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Inaba S, Ikeda T, Goto M, Tanaka H, Takahashi M, Iwabuchi H, Izumi T. Pharmacokinetics and disposition of CS-0777, a sphingosine 1-phosphate receptor modulator, in rats and monkeys. Xenobiotica. 2015;45(12):1063-80. doi: 10.3109/00498254.2015.1039097. Epub 2015 Jun 18. PubMed PMID: 26084376. 2. Lukas S, Patnaude L, Haxhinasto S, Slavin A, Hill-Drzewi M, Horan J, Modis LK. No differences observed among multiple clinical S1P1 receptor agonists (functional antagonists) in S1P1 receptor down-regulation and degradation. J Biomol Screen. 2014 Mar;19(3):407-16. doi: 10.1177/1087057113502234. Epub 2013 Sep 3. PubMed PMID: 24003058. 3. Sakurai H, Kubota K, Inaba S, Takanaka K, Shinagawa A. Identification of a metabolizing enzyme in human kidney by proteomic correlation profiling. Mol Cell Proteomics. 2013 Aug;12(8):2313-23. doi: 10.1074/mcp.M112.023853. Epub 2013 May 14. PubMed PMID: 23674616; PubMed Central PMCID: PMC3734587. 4. Moberly JB, Ford DM, Zahir H, Chen S, Mochizuki T, Truitt KE, Vollmer TL. Pharmacological effects of CS-0777, a selective sphingosine 1-phosphate receptor-1 modulator: results from a 12-week, open-label pilot study in multiple sclerosis patients. J Neuroimmunol. 2012 May 15;246(1-2):100-7. doi: 10.1016/j.jneuroim.2012.03.007. Epub 2012 Mar 31. PubMed PMID: 22465063. |