| Description | Crocin (Gardenia Yellow) is a water-soluble carotenoid pigment of saffron (Crocus sativus L. ) that has been used as a spice for flavoring and coloring food preparations, and in Chinese traditional medicine as an anodyne or tranquilizer. Crocin suppresses tumor necrosis factor (TNF)alpha-induced apoptosis of pheochromocytoma (PC12) cells by modulating mRNA expressions of Bcl-2 family proteins, which trigger downstream signals culminating in caspase-3 activation followed by cell death. Crocin prevented the activation of nSMase by enhancing the transcription of gamma-glutamylcysteinyl synthase, which contributes to a stable glutathione supply that blocks the activity of nSMase. |
| Synonyms | 西红花苷, 藏红花, Gardenia Yellow, Alpha-Crocin, 藏红花素 |
| molecular weight | 976.96 |
| Molecular formula | C44H64O24 |
| CAS | 42553-65-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 9.77 mg/mL (10 mM) |
| References | 1. Sapanidou V, et al. Theriogenology. 2015 Nov;84(8):1273-82. 2. Liu Y, Yao C, Wang Y, et al. Protective Effect of Crocin on Liver Function and Survival in Rats With Traumatic Hemorrhagic Shock[J]. Journal of Surgical Research. 2021, 261: 301-309. 3. Lu J, Lu Z, Liu L, et al. Identification of crocin as a new hIAPP amyloid inhibitor via a simple yet highly biospecific screening system[J]. Chemistry & Biodiversity. 2021 |
| Citations | 1. Lu J, Lu Z, Liu L, et al. Identification of crocin as a new hIAPP amyloid inhibitor via a simple yet highly biospecific screening system. Chemistry & Biodiversity. 2021 2. Liu Y, Yao C, Wang Y, et al. Protective Effect of Crocin on Liver Function and Survival in Rats With Traumatic Hemorrhagic Shock. Journal of Surgical Research. 2021, 261: 301-309. 3. Xiaodong X, Tao L, Jianmin L, et al.Crocin Inhibits the Type 2 Inflammatory Response Produced by ILC2s in Eosinophilic Nasal Polyps.American Journal of Rhinology & Allergy.2023: 19458924231185296. |