| Description | Crisdesalazine (AAD 2004) is an inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1). Crisdesalazine reduces autophagosome formation, axonopathy, and motor neuron degeneration, improving motor function and increasing life span. |
| Synonyms | AAD2004, AAD 2004, AAD-2004 |
| molecular weight | 325.28 |
| Molecular formula | C16H14F3NO3 |
| CAS | 927685-43-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 3.26 mg/mL (10.01 mM), Sonication is recommended. |
| References | 1. Baek IS, et al. AAD-2004 Attenuates Progressive Neuronal Loss in the Brain of Tg-betaCTF99/B6 Mouse Model of Alzheimer Disease. Exp Neurobiol. 2013 Mar;22(1):31-7. 2. Shin JH, et al. Concurrent blockade of free radical and microsomal prostaglandin E synthase-1-mediated PGE2 production improves safety and efficacy in a mouse model of amyotrophic lateral sclerosis. J Neurochem. 2012 Sep;122(5):952-61. |