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CRA1000

CAS No.: 226948-11-4

CRA1000, a CRF1 receptor antagonist, involved in the regulation of stress response.
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Description CRA1000, a CRF1 receptor antagonist, involved in the regulation of stress response.
Synonyms CRA 1000, CRA-1000
molecular weight 476.65
Molecular formula C28H33FN4S
CAS 226948-11-4
Storage Powder: -20°C for 3 years | In solvent: -80°C for 1 year
References 1. Knapp DJ, Overstreet DH, Moy SS, Breese GR. SB242084, flumazenil, and CRA1000 block ethanol withdrawal-induced anxiety in rats. Alcohol. 2004 Feb;32(2):101-11. PubMed PMID: 15163561; PubMed Central PMCID: PMC2871682. 2. Ohata H, Arai K, Shibasaki T. Effect of chronic administration of a CRF(1) receptor antagonist, CRA1000, on locomotor activity and endocrine responses to stress. Eur J Pharmacol. 2002 Dec 20;457(2-3):201-6. PubMed PMID: 12464367. 3. Chaki S, Okuyama S, Nakazato A, Kumagai T, Okubo T, Ikeda Y, Oshida Y, Hamajima Y, Tomisawa K. In vitro pharmacological profile of nonpeptide CRF1 receptor antagonists, CRA1000 and CRA1001. Eur J Pharmacol. 1999 Apr 29;371(2-3):205-11. PubMed PMID: 10357258. 4. Okuyama S, Chaki S, Kawashima N, Suzuki Y, Ogawa S, Nakazato A, Kumagai T, Okubo T, Tomisawa K. Receptor binding, behavioral, and electrophysiological profiles of nonpeptide corticotropin-releasing factor subtype 1 receptor antagonists CRA1000 and CRA1001. J Pharmacol Exp Ther. 1999 May;289(2):926-35. PubMed PMID: 10215672.