| Description | CPPG is a potent antagonist of group II/III mGlu receptors. CPPG exhibits some selectivity (approximately 20 fold) for group III (IC50: 2.2 nM) over group II (IC50: 46.2 nM) mGlu receptors in the rat cerebral cortex. |
| In vitro | CPPG ((RS)-CPPG) potently reversed both L-AP4 (IC50: 2.2 nM)- and L-CCG-I (IC50: 46.2 nM) -mediated inhibition of forskolin-stimulated cyclic AMP accumulation in adult rat cortical slices. CPPG has weak effects at the group I mGlu receptors in both the neonatal rat cortex and cultured cerebellar granule cells. |
| Target activity | mGlu receptor (Group II):46.2 nM (IC50), mGlu receptor (Group III):2.2 nM (IC50) |
| Synonyms | (RS)-CPPG |
| molecular weight | 271.21 |
| Molecular formula | C11H14NO5P |
| CAS | 183364-82-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Toms NJ, et al. The effects of (RS)-alpha-cyclopropyl-4-phosphonophenylglycine ((RS)-CPPG), a potent and selective metabotropic glutamate receptor antagonist. Br J Pharmacol. 1996 Nov;119(5):851-4. |