| Description | CP-96486 is a potent and orally active antagonist of leukotriene D4 (LTD4)/platelet activating factor (PAF) receptor (Kis: 20 and 24 nM). |
| In vitro | CP-96486 antagonizes 3H-LTD4 binding to guinea pig lung membranes and 3H-PAF binding to rabbit platelets (Kis: 20 and 24 nM). |
| In vivo | In guinea pigs, CP-96486 inhibits iv LTD4- and iv PAF-induced bronchoconstriction (ED50s: 0.27 and 0.26 mg/kg p.o.). |
| Target activity | LTD4:20 nM (ki), PAF receptor:24 nM (ki) |
| molecular weight | 502.99 |
| Molecular formula | C31H23ClN4O |
| CAS | 139401-45-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. A.Marfat,et al. The discovery of CP-96,021 and CP-96,486, balanced, combined, potent and orally active leukotriene D4(LTD4)/platelet activating factor (PAF) receptor antagonists. |