| Description | CP-640186 hydrochloride (CP 640186 HCl) is an isozyme-nonselective acetyl-CoA carboxylase (ACC) inhibitor, including rat liver ACC1 (IC50: 53 nM) and rat skeletal muscle ACC2 (IC50: 61 nM); with higher metabolic stability than CP-610431. |
| Target activity | ACC2:61 nM, ACC1:53 nM |
| Synonyms | CP 640186 HCl, 盐酸CP-640186 |
| molecular weight | 522.08 |
| Molecular formula | C30H36ClN3O3 |
| CAS | 591778-70-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 50 mg/mL (95.77 mM) |
| References | 1. Harwood HJ Jr, et al. J Biol Chem. 2003 Sep 26;278(39):37099-111. ; 2. Yamashita T, et al. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6314-8.; |