| Description | Cosalane (NSC 658586) is an HIV replication inhibitor, an inhibitor of chemokine receptor 7 (CCR7) signalling in humans and mice, with antiviral activity that blocks the binding of CCR7 to its natural ligands, CCL19 and CCL21. |
| Synonyms | NSC 658586, NSC-658586, NSC 640067 |
| molecular weight | 767.86 |
| Molecular formula | C45H60Cl2O6 |
| CAS | 154212-56-3 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 100 mg/mL (130.23 mM), Sonication is recommended. |
| References | 1. Kenneth A Fowler, et al. The Ex Vivo Treatment of Donor T Cells with Cosalane, an HIV Therapeutic and Small-Molecule Antagonist of CC-Chemokine Receptor 7, Separates Acute Graft-versus-Host Disease from Graft-versus-Leukemia Responses in Murine Hematopoietic Stem Cell Transplantation Models. Biol Blood Marrow Transplant. 2019 Jun;25(6):1062-1074. 2. Emily A Hull-Ryde, et al. Identification of Cosalane as an Inhibitor of Human and Murine CC-Chemokine Receptor 7 Signaling via a High-Throughput Screen. SLAS Discov. 2018 Dec;23(10):1083-1091. 3. Golebiewski WM, Keyes RF, Cushman M. Exploration of the effects of linker chain modifications on anti-HIV activities in a series of cosalane analogues. Bioorg Med Chem. 1996 Oct;4(10):1637-48. PubMed PMID: 8931933. 4. Kuchimanchi KR, Gandhi MD, Sheta RR, Johnston TP, Santhosh KC, Cushman M, Mitra AK. Intestinal absorption and biodistribution of cosalane and its amino acid conjugates: novel anti-HIV agents. Int J Pharm. 2002 Jan 14;231(2):197-211. PubMed PMID: 11755272. |