| Description | (-)-Corynoxidine is an AChE inhibitor derived from tubers of Stephania succifera. Corynoxidine exhibits antibacterial activities against Staphylococcus aureus and methicillin-resistant Staphylococcus aureus strains in different degrees. |
| In vitro | (-)-Corynoxidine以剂量依赖的方式抑制AChE活性，其IC50值为89.0 μM[2]。 |
| Target activity | AChE:89.0 μM (IC50) |
| Synonyms | Corynoxidine |
| molecular weight | 371.43 |
| Molecular formula | C21H25NO5 |
| CAS | 57906-85-1 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 20 mg/mL (53.9 mM), Sonication and heating to 60℃ are recommended. |
| References | 1. Yang DL, et al. A new antibacterial denitroaristolochic acid from the tubers of Stephania succifera. J Asian Nat Prod Res. 2013;15(3):315-8. 2. Kim DK, et al. Acetylcholinesterase inhibitors from the aerial parts of Corydalis speciosa. Arch Pharm Res. 2004 Nov;27(11):1127-31. |