| Description | Congo Red (Direct Red 28) is an azo dye. It binding been used as a diagnostic test for the presence of amyloid in tissue sections. |
| In vitro | Congo Red 组织化学染色可能作为一种简单的工具，用于探究突变细胞中的聚集体是否具有错误折叠的 β-折叠板二级结构[1]。Congo Red 组织化学染料能特异性地结合到交叉的 β-折叠板结构上。野生型 HSPB1 通过结合非天然构象的蛋白质来维持蛋白质稳态，从而防止底物聚集。然而，T139M 突变体在这一功能上失败，导致错误折叠蛋白质的积累，这些蛋白质是 Congo Red 的靶标，用于插入 β-折叠板结构之间。 |
| Synonyms | 刚果红, Direct Red 28 |
| molecular weight | 696.66 |
| Molecular formula | C32H22N6Na2O6S2 |
| CAS | 573-58-0 |
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 100 mg/mL (143.54 mM), Sonication is recommended. H2O: 4.16 mg/mL (5.97 mM), Sonication and heating are recommended. |
| References | 1. Amornvit J, et al. A novel p.T139M mutation in HSPB1 highlighting the phenotypic spectrum in a family. Brain Behav. 2017 Jul 21;7(8):e00774. |