Compound 48/80 trihydrochloride Bioactivity,Chemical Properties,Storage & Solubility Information Pathways-PeptideDB

Description	Compound 48/80 trihydrochloride (C48/80 trihydrochloride) is a mixture of N-methyl-p-methoxyphenethylamine and formaldehyde in a condensation reaction.Compound 48/80 trihydrochloride is a mast cell degranulator and histamine releaser. Compound 48/80 trihydrochloride inhibits phosphatidylinositol-specific phospholipase C activity in human platelets.
In vitro	Compound 48/80 trihydrochloride inhibits both cytosolic and particulate phosphatidylinositol-specific phospholipase C activities with similar efficiency (IC50s: 2.1 μg/ml (supernatant) and 5.0 μg /ml (particulate fraction)). The aggregation of human platelets induced by ADP and PAF-acether is inhibited by Compound 48/80 [1].
In vivo	Compound 48/80 trihydrochloride causes oxidative stress in the rat adrenal gland through mast cell degranulation. Compound 48/80 trihydrochloride (0.75 mg/kg; i.p.; Killed after 0.5, 3, or 6 h) increases serum serotonin, histamine, and corticosterone levels at 0.5 h, but their increases were reduced thereafter [3].
Synonyms	C48/80 trihydrochloride
molecular weight	629.1
Molecular formula	C32H48Cl3N3O3
CAS	848035-21-2
Storage	store at low temperature　\|　Powder: -20°C for 3 years \| In solvent: -80°C for 1 year
Solubility	H2O: 12.58 mg/mL (20 mM), Sonication is recommended. DMSO: 6.29 mg/mL (10 mM), Sonication is recommended.
References	1. Bronner C, et al. Compound 48/80 is a potent inhibitor of phospholipase C and a dual modulator of phospholipase A2 from human platelet. Biochim Biophys Acta. 1987 Aug 15;920(3):301-5. 2. Schemann M, et al. The mast cell degranulator compound 48/80 directly activates neurons. PLoS One. 2012;7(12):e52104. 3. Kaida S, et al. Compound 48/80 causes oxidative stress in the adrenal gland of rats through mast cell degranulation. Free Radic Res. 2010 Feb;44(2):171-80.

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Compound 48/80 trihydrochloride

CAS No.: 848035-21-2