| Description | Coenzyme FO is a precursor for the synthesis of coenzyme F420, a light-trapping chromophore for DNA photolyase. |
| In vitro | Coenzyme FO 是 F420 合成过程中的一个中间体，而辅酶F420是一种在产甲烷和某些非产甲烷古菌中参与能量代谢、NADP还原、氧气解毒和亚硫酸盐还原的低还原电位电子载体，可通过F420依赖性氢化酶被还原，并在结核分枝杆菌中帮助抵御巨噬细胞的抗菌作用[3]。 |
| molecular weight | 363.32 |
| Molecular formula | C16H17N3O7 |
| CAS | 37333-48-5 |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | Ethanol: < 1 mg/mL (insoluble) DMSO: 8 mg/mL (22.02 mM), Sonication is recommended. |
| References | 1. Mills DJ, et al. De novo modeling of the F(420)-reducing [NiFe]-hydrogenase from a methanogenic archaeon by cryo-electron microscopy. Elife. 2013;2:e00218. Published 2013 Mar 5. 2. Philmus B, et al. Biosynthetic versatility and coordinated action of 5'-deoxyadenosyl radicals in deazaflavin biosynthesis. J Am Chem Soc. 2015;137(16):5406-5413. 3. de Poorter LMI, et al. Hydrogen concentrations in methane-forming cells probed by the ratios of reduced and oxidized coenzyme F420. Microbiology. 2005;151(Pt 5):1697‐1705. 4. Purwantini E, et al. Conversion of NO2 to NO by reduced coenzyme F420 protects mycobacteria from nitrosative damage. Proc Natl Acad Sci U S A. 2009;106(15):6333‐6338. |