| Description | CNT2 inhibitor-1 is a potent inhibitor of concentrative nucleoside transporter 2 (CNT2; IC50: 640 nM for hCNT2). |
| In vitro | CNT2 inhibitor-1 (compound 48) exhibits 81-fold more potent inhibitory activity than the parent compound 12. In addition, CNT2 inhibitor-1 exhibits inhibitory activity 1500-fold more potent than that of 2’-deoxy-5-fluorouridine, phlorizin, and 7,8,3’-trihydroxyflavone, which are well-known hCNT2 inhibitors[1]. |
| Target activity | CNT2 (human):640 nM |
| molecular weight | 448.47 |
| Molecular formula | C23H24N6O4 |
| CAS | 880155-70-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 45 mg/mL (100.34 mM), Sonication is recommended. |
| References | 1. Tatani K, et al. Identification of 8-aminoadenosine derivatives as a new class of human concentrative nucleoside transporter 2 inhibitors. ACS Med Chem Lett. 2015 Jan 28;6(3):244-8. |