| Description | CNS-5161 is an NMDA antagonist. |
| Synonyms | CNS 5161 |
| molecular weight | 351.92 |
| Molecular formula | C16H18ClN3S2 |
| CAS | 160754-76-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Biegon A, Gibbs A, Alvarado M, Ono M, Taylor S. In vitro and in vivo characterization of [3H]CNS-5161--a use-dependent ligand for the N-methyl-D-aspartate receptor in rat brain. Synapse. 2007 Aug;61(8):577-86. PubMed PMID: 17455246. 2. Forst T, Smith T, Schütte K, Marcus P, Pfützner A; CNS 5161 Study Group.. Dose escalating safety study of CNS 5161 HCl, a new neuronal glutamate receptor antagonist (NMDA) for the treatment of neuropathic pain. Br J Clin Pharmacol. 2007 Jul;64(1):75-82. PubMed PMID: 17391323; PubMed Central PMCID: PMC2000615. 3. Walters MR, Bradford AP, Fischer J, Lees KR. Early clinical experience with the novel NMDA receptor antagonist CNS 5161. Br J Clin Pharmacol. 2002 Mar;53(3):305-11. PubMed PMID: 11874394; PubMed Central PMCID: PMC1874317. 4. McGinnity CJ, Hammers A, Riaño Barros DA, Luthra SK, Jones PA, Trigg W, Micallef C, Symms MR, Brooks DJ, Koepp MJ, Duncan JS. Initial evaluation of 18F-GE-179, a putative PET Tracer for activated N-methyl D-aspartate receptors. J Nucl Med. 2014 Mar;55(3):423-30. doi: 10.2967/jnumed.113.130641. PubMed PMID: 24525206. |