| Description | CNBCA, a selective and potent competitive inhibitor of the SHP2 enzyme, exhibits an IC50 value of 0.87 μM. It binds to the full-length SHP2, effectively inhibiting its enzyme activity, as well as impeding pAkt and pERK1/2. Furthermore, CNBCA suppresses the proliferation of BT474 and MDA-MB468 cells, indicating potential utility in breast cancer research [1]. |
| In vitro | CNBCA (0.25、0.50、1、2 μM，48小时)明显抑制了SHP2介导的在BT474和MDA-MB468细胞中Akt与ERK1/2的激活，其IC50值约为1.0 μM [1]。在500 nM浓度作用24至72小时后，CNBCA显著抑制了BT474和MDA-MB468细胞的增殖 [1]。 |
| molecular weight | 426.55 |
| Molecular formula | C26H34O5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |