CMC-Na (Viscosity:800-1200 mPa.s) Bioactivity,Chemical Properties,Storage & Solubility Information Pathways-PeptideDB

Description	Sodium carboxymethyl cellulose (CMC-Na) (Viscosity:800-1200 mPa.s) is a water-soluble cellulose, commonly used as a co-solvent in animal experiments, and is essentially non-toxic to animals.
In vivo	方法：为检测体内抗肿瘤活性，将 AMG-510 (30 mg/kg in 0.5% Sodium carboxymethyl cellulose) 灌胃给药给携带人肺癌肿瘤 H358 的 Balb/C nude 小鼠，每天一次，持续四周。结果：AMG-510 抑制 H358 肿瘤生长。[1]方法：为检测体内抗肿瘤活性，将 cediranib (5 mg/kg in 5% Sodium carboxymethyl cellulose) 灌胃给药给携带小鼠结直肠癌肿瘤 MC38 的 C57BL/6J 小鼠，每周五次，持续八天。结果：Cediranib 抑制 MC38 肿瘤生长。[2]
Synonyms	羧甲基纤维素钠, Sodium carboxymethyl cellulose, CMC-Na (Viscosity:800-1200 mPa.s)
molecular weight	354.375
Molecular formula	C16H27NaO7
CAS	9004-32-4
Storage	store at -20°C \| Shipping with blue ice.
Solubility	DMSO: insoluble
References	1. Wu LL, et al. AMG-510 and cisplatin combination increases antitumor effect in lung adenocarcinoma with mutation of KRAS G12C: a preclinical and translational research. Discov Oncol. 2023 Jun 7;14(1):91. 2. Zhang J, et al. Cediranib enhances the transcription of MHC-I by upregulating IRF-1. Biochem Pharmacol. 2024 Mar;221:116036.
Citations	1. Wu L L, Jiang W M, Liu Z Y, et al.AMG-510 and cisplatin combination increases antitumor effect in lung adenocarcinoma with mutation of KRAS G12C: a preclinical and translational research.Discover Oncology.2023, 14(1): 91. 2. Lan H, Dong Z W, Zhang M Y, et al.Sinapic acid modulates oxidative stress and metabolic disturbances to attenuate ovarian fibrosis in letrozole‐induced polycystic ovary syndrome SD rats.Food Science & Nutrition.2024 3. Zhang J, Guo H, Wang L, et al.Cediranib enhances the transcription of MHC-I by upregulating IRF-1.Biochemical Pharmacology.2024: 116036.

PeptideDB

CMC-Na (Viscosity:800-1200 mPa.s)

CAS No.: 9004-32-4