| Description | cloxacepride is a CaM antagonist that is used to treat asthma disease. |
| In vitro | Cloxacepride（10(-5)-10(-4) M；肥大细胞）显著抑制了Con A诱导的组胺释放。这种抑制效应在增加预孵育时间至30分钟内并未减弱。相反，高于4 x 10(-5) M的Cloxacepride浓度引起了大量的组胺释放。这种效应通过增加样本中的肥大细胞数量无法缓解。这些结果表明Cloxacepride具有非常狭窄的治疗潜力。[1] |
| molecular weight | 468.37 |
| Molecular formula | C22H27Cl2N3O4 |
| CAS | 65569-29-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 4.68 mg/mL (10 mM), Sonication is recommended. |
| References | 1. Schmutzler W, et al. The effects of metoclopramide and cloxacepride on human mast cells from adenoidal tissues. Agents Actions. 1989;27(1-2):110-112. 2. Friedrich G, et al. Inhibitory effect of cloxacepride on compound 48/80-induced histamine and serotonin release from rat mast cells. Arch Int Pharmacodyn Ther. 1984;267(2):264-268. |