| Description | Clomifene is a selective estrogen receptor modulator (SERM), it has both estrogenic and anti-estrogenic activities. This agent causes the release of the pituitary gonadotropins follicle-stimulating hormone (FSH) and luteinizing hormone (LH), leading to ovulation. |
| Synonyms | Omifin, D, Chloramiphene, Clomiphene, Clomiphene free base, Citrate |
| molecular weight | 405.96 |
| Molecular formula | C26H28ClNO |
| CAS | 911-45-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: Soluble H2O: Insoluble |
| References | 1. Xi W, Liu S, Mao H, Yang Y, Xue X, Lu X. Use of letrozole and clomiphene citrate combined with gonadotropins in clomiphene-resistant infertile women with polycystic ovary syndrome: a prospective study. Drug Des Devel Ther. 2015 Nov 11;9:6001-8. doi: 10.2147/DDDT.S83259. eCollection 2015. PubMed PMID: 26648691; PubMed Central PMCID: PMC4651359. 2. Oktem M, Guler I, Erdem M, Erdem A, Bozkurt N, Karabacak O. Comparison of The Effectiveness of Clomiphene Citrate versus Letrozole in Mild IVF in Poor Prognosis Subfertile Women with Failed IVF Cycles. Int J Fertil Steril. 2015 Oct-Dec;9(3):285-91. Epub 2015 Oct 31. PubMed PMID: 26644850; PubMed Central PMCID: PMC4671387. 3. Liu W, Dong S, Li Y, Shi L, Zhou W, Liu Y, Liu J, Ji Y. Randomized controlled trial comparing letrozole with laparoscopic ovarian drilling in women with clomiphene citrate-resistant polycystic ovary syndrome. Exp Ther Med. 2015 Oct;10(4):1297-1302. Epub 2015 Aug 19. PubMed PMID: 26622481; PubMed Central PMCID: PMC4578114. 4. Chen C, Yan Q, Liu K, Zhou X, Xian Y, Liang D, Zhao X, Guo X, Quan S. Endometrial Receptivity Markers in Mice Stimulated With Raloxifene Versus Clomiphene Citrate and Natural Cycles. Reprod Sci. 2015 Nov 23. pii: 1933719115616496. [Epub ahead of print] PubMed PMID: 26603317. |