| Description | Clevudine triphosphate is a TTP analog that is able to inhibit protein priming independently of the deoxynucleoside triphosphate substrate. |
| Synonyms | L-FMAU-TP |
| molecular weight | 500.16 |
| Molecular formula | C10H16FN2O14P3 |
| CAS | 174625-00-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Jones SA, Murakami E, Delaney W, Furman P, Hu J. Noncompetitive inhibition of hepatitis B virus reverse transcriptase protein priming and DNA synthesis by the nucleoside analog clevudine. Antimicrob Agents Chemother. 2013 Sep;57(9):4181-9. doi: 10.1128/AAC.00599-13. Epub 2013 Jun 17. Erratum in: Antimicrob Agents Chemother. 2013 Nov;57(11):5788. PubMed PMID: 23774432; PubMed Central PMCID: PMC3754288. 2. Jang YO, Quan X, Das R, Xu S, Chung CH, Ahn CM, Baik SK, Kong ID, Park KS, Kim MY. High-dose clevudine impairs mitochondrial function and glucose-stimulated insulin secretion in INS-1E cells. BMC Gastroenterol. 2012 Jan 10;12:4. doi: 10.1186/1471-230X-12-4. PubMed PMID: 22230186; PubMed Central PMCID: PMC3288815. 3. Anderson DL. Clevudine for hepatitis B. Drugs Today (Barc). 2009 May;45(5):331-50. doi: 10.1358/dot.2009.45.5.1354223. Review. PubMed PMID: 19584963. 4. Niu C, Murakami E, Furman PA. Clevudine is efficiently phosphorylated to the active triphosphate form in primary human hepatocytes. Antivir Ther. 2008;13(2):263-9. PubMed PMID: 18505177. |