| Description | Clathrin-IN-1 is a inhibitor of clathrin, and inhibits clathrin-mediated endocytosis (CME) by associating with the terminal domain of clathrin. It has the potential for anti-cancer research. |
| In vitro | Clathrin-IN-1未影响clathrin到纺锤体的招募，但一旦定位便破坏了其功能。通过损失有丝分裂纺锤体的完整性并激活纺锤体组装检查点，Clathrin-IN-1使HeLa细胞停留在中期，这一现象模仿了clathrin缺失和aurora A激酶抑制的效果[1]。 |
| molecular weight | 473.36 |
| Molecular formula | C20H13BrN2O3S2 |
| CAS | 1332879-52-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 45 mg/mL (95.07 mM) |
| References | 1. Smith CM, et, al. Inhibition of clathrin by pitstop 2 activates the spindle assembly checkpoint and induces cell death in dividing HeLa cancer cells. Mol Cancer. 2013 Jan 17; 12:4. 2. Kumar GA, et, al. Leishmania donovani Internalizes into Host Cells via Caveolin-mediated Endocytosis. Sci Rep. 2019 Sep 2; 9(1): 12636. |