| Description | Cirazoline hydrochloride is a competitive full agonist of the α1A-adrenergic receptor (α1A-AR; Ki: 120 nM). It is a partial agonist at α1B-AR (Ki: 960 nM) and α1D-AR (Ki: 660 nM). |
| In vitro | Cirazoline hydrochloride (5-10 μM; 24 hours) does not alter GIC survival. And it counteracted only poorly prazosin‐induced GIC death[1]. |
| In vivo | Cirazoline hydrochloride (drinking water; 40 μM; 9 months) shows significantly decreased immobility in the TST. However, it enhances neurogenesis in the mouse [1]. |
| Synonyms | LD 3098 hydrochloride |
| molecular weight | 252.74 |
| Molecular formula | C13H17ClN2O |
| CAS | 40600-13-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Doze VA, et al. alpha(1A)- and alpha(1B)-adrenergic receptors differentially modulate antidepressant-like behaviorin the mouse.Brain Res. 2009 Aug 18;1285:148-57. 2. Suzana Assad Kahn , et al. The Anti-Hypertensive Drug Prazosin Inhibits Glioblastoma Growth via the PKCδ-dependent Inhibition of the AKT Pathway. EMBO Mol Med. 2016 May 2;8(5):511-26. |