| Description | Cimicifugoside H1 shows the protective function to cerebral neuron during cerebral ischemia. |
| In vitro | 通过常规和反相柱色谱法对化合物进行了分离和纯化。其结构通过光谱分析鉴定。随后研究了它们的破骨细胞抑制活性。从C. foetida的块茎中分离出了十三种环烷酸三萜类化合物，分别鉴定为25-O-乙酰基-西米根醇(1)、西米根醇(2)、西米酮醇(3)、26-去氧精蓍素(4)、亚洲苦苷A(5)、23-表-26-去氧精蓍素(6)、精蓍素(7)、12β-羟基西米根醇(8)、西米苷E(9)、(23R, 24S) 25-O-乙酰基-西米根醇-3-O-β-D-吡喃木糖苷(10)、(23R, 24S) 西米根醇-3-O-β-D-吡喃木糖苷(11)、Cimicifugoside H-1 (12)和升麻苷H2 (13)。 |
| Synonyms | 黑升麻苷H-1 |
| molecular weight | 616.78 |
| Molecular formula | C35H52O9 |
| CAS | 163046-73-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 6.17 mg/mL (10 mM) |
| References | 1. Cycloartane triterpenoid of Cimicifuga foetida.Zhongguo Zhong Yao Za Zhi. 2009 Aug;34(15):1930-4. |
| Citations | 1. Hu H F, Han L, Fu J Y, et al.LINC00982-encoded protein PRDM16-DT regulates CHEK2 splicing to suppress colorectal cancer metastasis and chemoresistance.Theranostics.2024, 14(8): 3317. |