| Description | Cichoriin is a photosensitive compound, it could be used as herbal photosensitizing agent in treating benign breast tumor in rats. |
| In vitro | 方法与结果:从阿尔皮尼亚·加朗加(Alpinia galanga Swartz)根组织的内生菌Streptomyces sp. Tc052中分离得到四种黄酮类化合物,包括山奈酚(1)、异欧化酚(2)、伞形草酮(3)和 Cichoriin(4)。对这些化合物(1-4)进行了针对谷氨酸诱导的海马HT22细胞系细胞毒性的保护效果评估,结果显示化合物1和2在100 μM的浓度下分别显示出62.4+2.8%和55.3+3.4%的显著保护比率,而化合物3-4无活性。化合物1和2还表现出对DPPH自由基的强大清除作用,其IC50值分别为60.74 μM和75.65 μM。结论:这些结果表明化合物1和2可能具有针对氧化性细胞损伤的神经保护活性。 |
| molecular weight | 340.28 |
| Molecular formula | C15H16O9 |
| CAS | 531-58-8 |
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 60 mg/ml (176.33 mM) |
| References | 1. Cytoprotective Activity of Chemical Constituents Isolated from Streptomyces sp. International Journal of Biological Chemistry, 2009, 3(1):11-17. |