| Description | Cichoric Acid (Dicaffeoyltartaric acid) is a potent inhibitor of human immunodeficiency virus type-1 (HIV-1) integrase and the replication in tissues. It also a class of cannabinomimetics with CB2 receptor-dependent and independent. |
| Target activity | HIV-I integrase:0.8 μM |
| Synonyms | 菊苣酸, Dicaffeoyltartaric acid, Chicoric Acid |
| molecular weight | 474.37 |
| Molecular formula | C22H18O12 |
| CAS | 6537-80-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 347 mg/mL (731.50 mM) |
| References | 1. King P J, Robinson W E. Resistance to the anti-human immunodeficiency virus type 1 compound L-chicoric acid results from a single mutation at amino acid 140 of integrase[J]. Journal of virology, 1998, 72(10): 8420-8424. 2. Raduner S, et al. Alkylamides from Echinacea are a new class of cannabinomimetics. Cannabinoid type 2 receptor-dependent and -independent immunomodulatory effects.[J]. Journal of Biological Chemistry, 2006, 281(20):14192-14206. |
| Citations | 1. Zhang H, Liang B, Sang X, et al.Discovery of Potential Inhibitors of SARS-CoV-2 Main Protease by a Transfer Learning Method.Viruses.2023, 15(4): 891. |