| Description | Chymase-IN-1 is a selective, orally active inhibitor of human mast cell chymase (IC50: 29 nM). |
| In vitro | Chymase-IN-1具有36 nM的chymase Ki值和9500 nM的Cat G Ki值[1]。 |
| In vivo | Chymase-IN-1 在大鼠体内展现出低口服生物利用度（F=3%；口服t1/2=1.8小时）[1]。 |
| Target activity | Chymase:29 nM |
| molecular weight | 431.83 |
| Molecular formula | C20H15ClNO4PS |
| CAS | 862090-74-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 50 mg/mL (115.79 mM) |
| References | 1. Greco MN, et al. Discovery of potent, selective, orally active, nonpeptide inhibitors of human mast cell chymase. J Med Chem. 2007 Apr 19;50(8):1727-30. |