| Description | Cho-Arg is a steroid-based cationic lipid that contains a cholesterol skeleton coupled to an L-arginine head group. It forms a complex with plasmid DNA and decreases plasmid DNA migration in an agarose-gel retardant assay at charge ratios greater than or equal to 4. Cho-Arg facilitates transfection of plasmid DNA into H1299 and HeLa cells in the presence or absence of fetal bovine serum, an effect that is reversed by the lipid raft-mediated endocytosis inhibitor methyl-β-cyclodextrin and the caveolae-mediated endocytosis inhibitor genistein . It is cytotoxic to H1299 cells (IC50 = 88.5 μg/ml). |
| molecular weight | 884.059 |
| Molecular formula | C43H71F6N5O7 |
| CAS | 1609010-56-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMF: 50 mg/mL DMSO: 50 mg/mL Ethanol: 50 mg/mL Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/mL |
Cho-Arg (trifluoroacetate salt)
CAS No.: 1609010-56-1
Cho-Arg is a steroid-based cationic lipid that contains a cholesterol skeleton coupled to an L-arginine head group. It f
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