| Description | Chloroacetamido-PEG4-C2-Boc is a PEG-based PROTAC linker that incorporates alkyl and ether functionalities. This compound is utilized in synthesizing PROTACs, offering a versatile platform for targeted protein degradation. |
| In vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. |
| molecular weight | 397.89 |
| Molecular formula | C17H32ClNO7 |
| CAS | 1365655-90-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Wang Y, et al. Degradation of proteins by PROTACs and other strategies. Acta Pharm Sin B. 2020 Feb;10(2):207-238. |