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CHF 2819

CAS No.: 412044-92-9

CHF 2819 is a novel orally active acetylcholinesterase inhibitor (AChE) developed for the treatment of Alzheimer's disea
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Description CHF 2819 is a novel orally active acetylcholinesterase inhibitor (AChE) developed for the treatment of Alzheimer's disease (AD). CHF 2819 is a selective inhibitor of AChE, it is 115 times more potent against this enzyme than against butyrylcholinesterase (BuChE).
Synonyms Ganstigmine HCl, CHF-2819, Ganstigmine hydrochloride, CHF2819
molecular weight 403.9
Molecular formula C21H26ClN3O3
CAS 412044-92-9
Storage Powder: -20°C for 3 years | In solvent: -80°C for 1 year
References 1. Trabace L, Cassano T, Steardo L, Pietra C, Villetti G, Kendrick KM, Cuomo V. Biochemical and neurobehavioral profile of CHF2819, a novel, orally active acetylcholinesterase inhibitor for Alzheimer's disease. J Pharmacol Exp Ther. 2000 Jul;294(1):187-94. PubMed PMID: 10871311. 2. Bartolucci C, Siotto M, Ghidini E, Amari G, Bolzoni PT, Racchi M, Villetti G, Delcanale M, Lamba D. Structural determinants of Torpedo californica acetylcholinesterase inhibition by the novel and orally active carbamate based anti-alzheimer drug ganstigmine (CHF-2819). J Med Chem. 2006 Aug 24;49(17):5051-8. PubMed PMID: 16913695. 3. Jhee SS, Fabbri L, Piccinno A, Monici P, Moran S, Zarotsky V, Tan EY, Frackiewicz EJ, Shiovitz T. First clinical evaluation of ganstigmine in patients with probable Alzheimer's disease. Clin Neuropharmacol. 2003 May-Jun;26(3):164-9. PubMed PMID: 12782920. 4. Trabace L, Cassano T, Loverre A, Steardo L, Cuomo V. CHF2819: pharmacological profile of a novel acetylcholinesterase inhibitor. CNS Drug Rev. 2002 Spring;8(1):53-69. Review. PubMed PMID: 12070526.