| Description | CGRP (83-119), rat TFA (Calcitonin Gene Related Peptide(83-119), rat TFA) is a 37 amino acid calcitonin family of neuropeptide, acts through calcitonin receptor-like receptor. |
| In vitro | CGRP (83-119), rat TFA(CGRP) (83-119), 属于降钙素家族的神经肽，该家族还包括降钙素、肾上腺髓质素、淀粉样蛋白、降钙素、中间素和降钙素受体刺激肽。CGRP 具有两种异构体(αCGRP 和 βCGRP)，通过降钙素样受体(CRLR)发挥作用[1]。CGRP 在偏头痛的病理生理学中起关键作用，与三叉神经血管系统的激活有关。CGRP 可能在这些涉及原发性头痛的区域后接头地发挥作用[2]。 |
| In vivo | Calcitonin Gene Related Peptide, CGRP (83-119), rat TFA是一种在鼠面部组织中引发水肿的强效诱导剂。CGRP (100 μL; 8-33 pM)能迅速（5-15分钟）且持久（6小时）地按剂量依赖性引导鼠脸颊发生水肿。CGRP同样在鼠后爪引起较小的水肿效果，此效应可被CGRP拮抗剂阻断。CGRP (16 pM)可增强与物质P (3.7 nM)[3]共同注射时所引起的水肿。 |
| Synonyms | Calcitonin Gene Related Peptide(83-119), rat TFA |
| molecular weight | 3920.32 |
| Molecular formula | C162H262N50O52S2.C2HF3O2 |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | H2O: 10 mg/mL (2.55 mM), Sonication is recommended. |
| References | 1. S. Ghatta, et al. Calcitonin gene-related peptide: Understanding its role. Educational Forum. 20.6.2004. |