| Description | CGP 20376 is a benzothiazole compound, an anthelmintic, with dual dose-dependent modulation of in vitro effects on the respiratory burst of eosinophils and antifibrillatory properties. |
| In vitro | CGP 20376 (1μg/ml) 在24小时内暴露后能够使98-100%的运动能力下降。当化合物浓度为1μg/ml时，1小时暴露后CGP 20376能够不可逆地使100%的微丝蚴完全定止。相反，在同等条件下，CGP 6140在一小时后并未显示出显著的定止效果。[5] |
| In vivo | CGP 20376（口服20 mg/kg）迅速而显著地减少了皮肤中的微丝蚴密度，但到了第137天后，微丝蚴的皮肤密度接近治疗前水平。到了第137天，CGP 20376处理的动物中几乎完全中断了胚胎发育，且大多数剩余的宫内微丝蚴都出现了病理性改变。[1] |
| Synonyms | CGP-20376, CGP20376 |
| molecular weight | 384.54 |
| Molecular formula | C16H20N2O3S3 |
| CAS | 81059-04-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Renz A, et al. Evaluation of suramin, ivermectin and CGP 20376 in a new macrofilaricidal drug screen, Onchocerca ochengi in African cattle. Trop Med Parasitol. 1995 Mar;46(1):31-7. 2. Tischendorf FW, et al. Modulatory effects of antifilarial drugs ivermectin, CGP 6140 and CGP 20376 on the oxidative burst of eosinophilic granulocytes. Acta Trop. 1993 Mar;53(1):27-37. 3. Chandrashekar R, et al. Effect of CGP 20376 on Brugia malayi and parasite antigenemia in jirds. J Parasitol. 1991 Jun;77(3):479-82. 4. Mak JW, et al. Antifilarial activity of CGP 20376 against subperiodic Brugia malayi in the leaf-monkey Presbytis cristata. Trop Med Parasitol. 1990 Mar;41(1):10-2. 5. Strote G. In vitro study on the effect of the new chemotherapeutic agents CGP 6140 and CGP 20376 on the microfilariae of Onchocerca volvulus. Trop Med Parasitol. 1987;38(3):211-213. |