| Description | Cevimeline, a parasympathomimetic and muscarinic agonist, affects M1 and M3 receptors. Cevimeline has been shown to treat dry mouth and Sj gren's syndrome. It is also used to reduce Xerostomia symptoms and increase salivary flow in head and neck cancer survivors after radiotherapy. |
| Synonyms | AF-102B, 西维美林, FKS 508, SNI 2011, HSDB 7286 |
| molecular weight | 199.31 |
| Molecular formula | C10H17NOS |
| CAS | 107233-08-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: Soluble |
| References | 1. Barbe AG. Long-term Use of the Sialogogue Medications Pilocarpine and Cevimeline Can Reduce Xerostomia Symptoms and Increase Salivary Flow in Head and Neck Cancer Survivors After Radiotherapy. J Evid Based Dent Pract. 2017 Sep;17(3):268-270. doi: 10.1016/j.jebdp.2017.06.013. Epub 2017 Jul 3. PubMed PMID: 28865825. 2. Mitoh Y, Ueda H, Ichikawa H, Fujita M, Kobashi M, Matsuo R. Effects of cevimeline on excitability of parasympathetic preganglionic neurons in the superior salivatory nucleus of rats. Auton Neurosci. 2017 Sep;206:1-7. doi: 10.1016/j.autneu.2017.05.010. Epub 2017 May 30. PubMed PMID: 28600120. |