| Description | Ceritinib D7 (LDK378 D7) is a deuterium-labeled Ceritinib. Ceritinib is an ATP-competitive inhibitor of ALK tyrosine kinase. |
| Synonyms | LDK378 D7 |
| molecular weight | 565.18 |
| Molecular formula | C28H36ClN5O3S |
| CAS | 1632484-77-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Marsilje TH, et al. Synthesis, structure-activity relationships, and in vivo efficacy of the novel potent and selective anaplastic lymphoma kinase (ALK) inhibitor 5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (LDK378) currently in phase 1 and phase 2 clinical trials. J Med Chem. 2013 Jul 25;56(14):5675-90. |