| Description | Cefepime dihydrochloride, a broad-spectrum fourth-generation cephalosporin, binds and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. |
| Synonyms | Cefepime hydrochloride anhydrous, BMY-28142 dihydrochloride, Cepimax, Axepim, Cefepime HCl |
| molecular weight | 553.48 |
| Molecular formula | C19H26Cl2N6O5S2 |
| CAS | 107648-80-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: Soluble |
| References | 1. Jagadeesh Kumar V, Badarinadh Gupta P, Pavan Kumar KS, Prasada Rao KV, Rao KR, Prasanna SJ, Kumar Sharma H, Mukkanti K. Identification and characterization of new degradation products of cefepime dihydrochloride monohydrate drug substance during stress stability studies. Anal Sci. 2010;26(10):1081-6. PubMed PMID: 20953052. 2. Jiang X, Zhang Z, Li M, Zhou D, Ruan F, Lu Y. Detection of extended-spectrum beta-lactamases in clinical isolates of Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2006 Sep;50(9):2990-5. PubMed PMID: 16940093; PubMed Central PMCID: PMC1563526. 3. Zhao L, Guo JF, Zhang AJ, Zhao YM. [Rapid identification of the isomeric impurity in raw drug of cefepime dihydrochloride by liquid chromatography-tandem mass spectrometry]. Yao Xue Xue Bao. 2005 Apr;40(4):361-4. Chinese. PubMed PMID: 16011268. 4. Musiał W, Zajac M. Stability of cefepime dihydrochloride monohydrate in solid state. Acta Pol Pharm. 2002 Jul-Aug;59(4):243-6. PubMed PMID: 12403297. |