| Description | CDPPB is a modulator of mGluR5 positive allosteric(with an EC50 of 27 nM in Chinese hamster ovary cells expressing human mGluR5). |
| Target activity | mGluR5:27 nM (EC50) |
| molecular weight | 364.4 |
| Molecular formula | C23H16N4O |
| CAS | 781652-57-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 3.64 mg/mL (10 mM), Sonication is recommended. |
| References | 1. Kinney GG, et, al. A novel selective positive allosteric modulator of metabotropic glutamate receptor subtype 5 has in vivo activity and antipsychotic-like effects in rat behavioral models. J Pharmacol Exp Ther. 2005 Apr; 313(1):199-206. |
| Citations | 1. Li X, Du Z J, Xu J N, et al.mGluR5 in hippocampal CA1 pyramidal neurons mediates stress-induced anxiety-like behavior.Neuropsychopharmacology.2023: 1-11. |