| Description | CDK2 acetate is a member of the eukaryotic S/T protein kinase family and its function is to catalyze the phosphoryl transfer of ATP γ-phosphate to serine or threonine hydroxyl (denoted as S0/T0) in a protein substrate. |
| In vitro | CDK2（Cyclin-dependent kinase 2）是真核生物S/T蛋白激酶家族的成员，负责催化ATP γ-磷酸转移到蛋白质底物中的丝氨酸或苏氨酸羟基（标记为S0/T0）上。与最佳肽底物HHASPRK形成复合物的CDK2处于完全活跃状态，即CDK2与肽底物的相互作用及G-环的动态过程。CDK2在真核细胞周期的G1/S边界处参与调控。已证实CDK2在肿瘤细胞中的失调，引起了对人工和天然抑制剂的极大兴趣。CDK2的活性通过复杂机制紧密调控，包括正向调节亚单位的结合，以及在正向和/或负向调节位点的磷酸化。 |
| molecular weight | 891.99 |
| Molecular formula | C37H61N15O11 |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Bártová I, The mechanism of inhibition of the cyclin-dependent kinase-2 as revealed by the molecular dynamics study on the complex CDK2 with the peptide substrate HHASPRK. Protein Sci. 2005 Feb;14(2):445-51. |