| Description | CDK/HDAC-IN-2 is a potent dual HDAC/CDK inhibitor that acts on HDAC1 (IC50: 6.4 nM), HDAC2 (IC50: 0.25 nM), HDAC3 (IC50: 45 nM), HDAC6,8 (IC50>1000 nM), CDK1 (IC50: 8.63 nM), CDK4,6,7 (IC50>1000 nM), CDK2 (IC50: 0.30 nM), CDK4,6,7 (IC50>1000 nM). CDK2 (IC50: 0.30 nM), CDK4,6,7 (IC50>1000 nM). CDK/HDAC-IN-2 can arrest the cell cycle in G2/M phase and induce apoptosis. CDK/HDAC-IN-2 has excellent anti-proliferative effects and shows significant anti-tumor effects. |
| molecular weight | 523.37 |
| Molecular formula | C25H20Cl2N6O3 |
| CAS | 2580938-58-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |