| Description | CDDO-2P-Im shows chemopreventive effect and reduces the size and severity of the lung tumors in the mouse lung cancer model. |
| In vitro | 在RAW264.7细胞中，CDDO-2P-Im可以抑制NO的生成（IC50：5.8 nM）。CDDO-2P-Im（100 nM）能诱导U937细胞分化[1]。 |
| In vivo | CDDO-2P-Im 显著提升了血红素加氧酶-1和醌还原酶的 mRNA 以及蛋白质水平。在A/J小鼠中，CDDO-2P-Im（50-200 mg/kg）降低了肿瘤的数量、大小及其严重程度[1]。 |
| Synonyms | CDDO-2-P-Im |
| molecular weight | 618.81 |
| Molecular formula | C39H46N4O3 |
| CAS | 1883650-96-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 112.5 mg/mL (181.8 mM), Sonication is recommended. |
| References | 1. Cao M , et al. Novel synthetic pyridyl analogues of CDDO-Imidazolide are useful new tools in cancer prevention. Pharmacol Res. 2015 Oct;100:135-47. 2. Cao M , et al. Novel synthetic pyridyl analogues of CDDO-Imidazolide are useful new tools in cancer prevention. Pharmacol Res. 2015 Oct;100:135-47. |