| Description | CDC25B-IN-1 is an inhibitor of CDC25B with a Ki of 8.5 μM. CDC25B-IN-1 increases the G2/M phase by inhibiting cell proliferation and colony formation. |
| Target activity | CDC25B phosphatase:ki： 8.5 μM |
| Synonyms | ethyl 3-[(3-methoxynaphthalen-1-yl)amino]benzoate |
| molecular weight | 321.37 |
| Molecular formula | C20H19NO3 |
| CAS | 2374831-10-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 90 mg/mL (280.1 mM), Sonication is recommended. |
| References | 1. Cerchia C, et al. Discovery of Novel Naphthylphenylketone and Naphthylphenylamine Derivatives as Cell Division Cycle 25B (CDC25B) Phosphatase Inhibitors: Design, Synthesis, Inhibition Mechanism, and in Vitro Efficacy against Melanoma Cell Lines. J Med Chem. 2019 Aug 8;62(15):7089-7110. |