| Description | CD38 inhibitor 1 is an inhibitor of CD38. For hCD38 and mouse CD38, the IC50s are 7.3 nM and 1.9 nM. |
| In vivo | In liver and muscle, CD38 inhibitor (30 mg/kg; oral administration; 2 and 6 hours) obviously elevates NAD levels [1]. |
| Target activity | CD38:1.9 nM(mouse), CD38:7.3 nM(human) |
| molecular weight | 413.53 |
| Molecular formula | C22H27N3O3S |
| CAS | 1700637-55-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 65 mg/mL (157.18 mM), Sonication is recommended. |
| References | 1. Haffner CD, et al. Discovery, Synthesis, and Biological Evaluation of Thiazoloquin(az)olin(on)es as Potent CD38 Inhibitors. J Med Chem. 2015 Apr 23;58(8):3548-71. |