| Description | Potent Chk2 inhibitor (IC50 = 3 nM). Shows >63-fold selectivity for Chk1 over Chk2 and a panel of 84 other kinases. Inhibits Chk2 activation in response to etoposide-induced DNA damage in HT29 cells. Blocks ionizing radiation-induced apoptosis of mouse thymocytes. |
| Target activity | Chk1:245 nM (IC50), Chk2:1.16 nM (Ki), Chk2:3 nM (IC50) |
| Synonyms | CCT 241533 dihydrochloride |
| molecular weight | 515.41 |
| Molecular formula | C23H29Cl2FN4O4 |
| CAS | 1962925-28-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: Soluble |
| References | 1. Caldwell et al (2011) Structure-based design of potent and selective 2-(quinazolin-2-yl)phenol inhibitors of checkpoint kinase 2. J.Med.Chem. 54 580 PMID:21186793 |