| Description | CCR1 antagonist 9 is an effective and selective CCR1 antagonist (IC50: 6.8 nM in calcium flux assay). |
| In vitro | CCR1 antagonist 9 (Compound 19e) blocks the CCR1 chemotaxis of THP-1 cells (IC50: 28 nM) and also blocks hERG (IC50: 30 μM). |
| Target activity | CCR1:6.8 nM |
| molecular weight | 425.44 |
| Molecular formula | C20H16FN5O3S |
| CAS | 1220026-26-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Harcken C, et al. Identification of novel azaindazole CCR1 antagonist clinical candidates. Bioorg Med Chem Lett. 2019 Feb 1;29(3):441-448. |