| Description | CBS1117 is a virus entry inhibitor (IC50 of 70 nM for influenza A virus, A/Puerto Rico/8/34 (H1N1)）. It interferes with the hemagglutinin (HA)-mediated fusion process. |
| In vitro | CBS1117 which has a 50% inhibitory concentration of 70 nM and a selectivity index of ~4000 against A/Puerto Rico/8/34 (H1N1) infection in human lung epithelial cell line (A549). |
| Target activity | H1N1:70 nM (IC50) |
| molecular weight | 315.24 |
| Molecular formula | C15H20Cl2N2O |
| CAS | 959245-08-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 13 mg/mL (41.24 mM) |
| References | 1. Hussein AFA, et al. Identification of entry inhibitors with 4-aminopiperidine scaffold targeting group 1 influenza A virus. Antiviral Res. 2020 May;177:104782. |