| Description | CB-6644 is a selective inhibitor of the RUVBL1/2 complex and blocks the ATPase activity of RUVBL1/2 (IC50 = 15 nM). |
| In vitro | CB-6644 (20 μM) interacts with the RUVBL1/2 complex in Ramos cells. CB-6644 (0.001-10 μM; 72 hours) potently kills 123 cell lines (EC50: 41 to 785 nM). |
| In vivo | CB-6644 (150 mg/kg, p.o., 30 days of treatment for SCID-beige mice bearing RPMI8226 xenograft models, 10 days of treatment for SCID-beige mice bearing Ramos xenograft models) has antitumor activity in xenograft tumor models. The tumor growth inhibitions (TGIs) are 68 and 81%, respectively in Ramos xenograft models and RPMI8226 xenograft models. |
| Target activity | RUVBL1/2:15 nM |
| molecular weight | 573.06 |
| Molecular formula | C29H34ClFN4O5 |
| CAS | 2316817-88-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 1 mg/mL, Sonication is recommended. |
| References | 1. Assimon VA, et al. CB-6644 Is a Selective Inhibitor of the RUVBL1/2 Complex with Anticancer Activity. ACS Chem Biol. 2019 Feb 15;14(2):236-244. |