| Description | CAY10781 is an inhibitor of the protein-protein interaction between neuropilin-1 (NRP-1) and VEGF-A.1It inhibits the interaction by 43% when used at a concentration of 12.5 μM. CAY10781 also inhibits VEGF-A-induced phosphorylation of VEGFR2 in catecholamine A-differentiated (CAD) cells when used at the same concentration. |
| Synonyms | CAY10781 |
| molecular weight | 231.21 |
| Molecular formula | C11H9N3O3 |
| CAS | 1210360-87-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMF: Insoluble PBS (pH 7.2): Insoluble Ethanol: Insoluble DMSO: 10 mg/mL |
| References | 1. Perez-Miller, S., Patek, M., Moutal, A., et al.In silico identification and validation of inhibitors of the interaction between neuropilin receptor 1 and SARS-CoV-2 Spike proteinbioRxiv308783(2020) |