| Description | CaV1.3 antagonist-1 is a cyclopentyl derivative with the potential for the research of Parkinson's disease. CaV1.3 antagonist-1 inhibits Ca V 1.3 LTCC over 600-fold more effectively than Ca V 1.2 LTCC. CaV1.3 antagonist-1 is a potent and highly selective antagonist of Ca V 1.3 L-type calcium channel (LTCC) with an IC50 value of 1.7 μM [1]. |
| In vitro | CaV1.3 antagonist-1 (Compound 8; 5 μM) exhibits 31.2% and 4.4% inhibition for Ca V 1.3 and Ca V 1.2 channel current in HEK293 cells, respectively. This correlates with the results of the FLIPR assay [1]. |
| molecular weight | 334.8 |
| Molecular formula | C17H19ClN2O3 |
| CAS | 1391385-57-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |