| Description | Carviolin is an anthraquinone fungal metabolite that has been found inZ. longicaudatawith immunosuppressive and antitrypanosomal activities.1,2It inhibits LPS- or concanavalin A-induced proliferation of mouse splenocytes (IC50s = 4 and 4.5 μg/ml, respectively).1Carviolin is active againstT. b. brucei(MIC = 41.66 μM).2 |
| molecular weight | 300.26 |
| Molecular formula | C16H12O6 |
| CAS | 478-35-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | Methanol: Soluble DMSO: Soluble Ethanol: Soluble Dichloromethane: Soluble |
| References | 1. Fujimoto, H., Nakamura, E., Okuyama, E., et al.Six immunosuppressive features from an ascomycete, Zopfiella longicaudata, found in a screening study monitored by immunomodulatory activityChem. Pharm. Bull. (Tokyo)52(8)1005-1008(2004) 2. Aly, A.H., Debbab, A., Clements, C.M., et al.NF kappa B inhibitors and antitrypanosomal metabolites from endophytic fungus Penicillium sp. isolated from Limonium tubiflorumBioorg. Med. Chem.19(1)414-421(2011) |