| Description | Carbonic Anhydrase Inhibitor 12 is a potent inhibitor of CA II, with additional inhibitory activity against CA I, exhibiting K_i values of 1.72 nM for CA II and 271 nM for CA I. Moreover, it demonstrates significant anticancer activity across various cancer cell lines [1]. |
| In vitro | 碳酸脱水酶抑制剂12（化合物14h）（10 μM；48小时；单次处理）显著影响不同癌细胞系的特异性和抑制效能[1]。该抑制剂在MCF-7和MDA-MB-231细胞中以2.4 μM和2.5 μM的浓度处理48小时后，能够将细胞周期阻滞在G2/M期[1]。同样条件下，碳酸脱水酶抑制剂12使得MCF-7和MDA-MB-231细胞早期和晚期凋亡相较于未处理的对照细胞有所增加[1]。 |
| molecular weight | 640.53 |
| Molecular formula | C27H22BrN5O5S2 |
| CAS | 2883451-38-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
Carbonic anhydrase inhibitor 12
CAS No.: 2883451-38-3
Carbonic Anhydrase Inhibitor 12 is a potent inhibitor of CA II, with additional inhibitory activity against CA I, exhibi
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