| Description | Capzimin is a selective inhibitor of proteasome isopeptidase Rpn11. |
| In vitro | 在白血病细胞中，Capzimin在SR和K562细胞系表现出0.67 μM和1 μM的GI50值。对于非小细胞肺癌，Capzimin在NCI-H460细胞中显示出0.7 μM的GI50。在乳腺癌中，Capzimin在MCF7细胞中的GI50为1.0 μM。Capzimin阻止了HCT116细胞的生长并诱导了凋亡[1]。 |
| molecular weight | 628.81 |
| Molecular formula | C30H24N6O2S4 |
| CAS | 2084868-04-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 50.1 mg/mL (79.7 mM) |
| References | 1. Li J, et al. Capzimin is a potent and specific inhibitor of proteasome isopeptidase Rpn11. Nat Chem Biol. 2017 May;13(5):486-493. |