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Calmodulin-Dependent Protein Kinase II 290-309 acetate

CAS No.:

Calmodulin-Dependent Protein Kinase II 290-309 acetate is an effective antagonist of Ca2+/calmodulin-dependent protein k
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Description Calmodulin-Dependent Protein Kinase II 290-309 acetate is an effective antagonist of Ca2+/calmodulin-dependent protein kinase II (IC50 = 52 nM).
In vitro 氨基末端的截断(肽296-309)或羧基末端的延长(肽294-319)对钙调蛋白的结合影响不大,而从羧基末端缩短肽链(肽290-302)或从两端同时缩短(肽295-304)则导致该活性消失[1]。
Target activity CaMK II:52 nM
Synonyms Calmodulin-Dependent Protein Kinase II 290-309 acetate (115044-69-4 Free base)
molecular weight 2333.88
Molecular formula C105H189N31O26S
Storage keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
References 1. Payne ME, et al. Calcium/calmodulin-dependent protein kinase II. Characterization of distinct calmodulin binding and inhibitory domains. J Biol Chem. 1988 May 25;263(15):7190-5.