Calcitonin（salmon） Acetate(47931-85-1(free base)) Bioactivity,Chemical Properties,Storage & Solubility Information Pathways-PeptideDB

Description	Calcitonin(salmon)Acetate(47931-85-1(free base))(Salmon calcitonin) , a calcium regulating hormone, is used to treat osteoporosis in women who are at least 5 years past menopause.
In vivo	口服Calcitonin salmon治疗在干预期间剂量依赖性地减轻了禁食和非禁食时的高血糖。研究结束时，口服Calcitonin salmon治疗通过剂量减少了大约9 mM的糖尿病高血糖，并降低了HbA1c水平1.7%。此外，在口服葡萄糖耐量测试期间，口服Calcitonin salmon治疗剂量依赖性地显著减少了葡萄糖波动。另外，口服Calcitonin salmon治疗在基础状态下，主要维持了高胰岛素血症，减轻了高胰高血糖素血症和总样胰高血糖素-1的过度分泌。最后，在研究结束时，口服Calcitonin salmon治疗剂量依赖性地改善了胰岛β细胞功能和β细胞区域。
Synonyms	Salmon calcitonin
molecular weight	3431.85
Molecular formula	C145H240N44O48S2
Storage	keep away from moisture\|Powder: -20°C for 3 years \| In solvent: -80°C for 1 year
Solubility	DMSO: 5 mM
References	1. Feigh M, et al. Oral salmon calcitonin attenuates hyperglycaemia and preserves pancreatic beta-cell area and function in Zucker diabetic fatty rats. Br J Pharmacol. 2012 Sep;167(1):151-63.

PeptideDB